Computational bone remodelling simulations and comparisons with DEXA results

Computational AGility for internal flows sImulations and compaRisons with Experiments

The environmental benefits of low emission lean burn technology in reducing NOx emissions up to 80% will only be effective when these are deployed to a large range of new aero-engine applications. While integrating methodologies for advanced engine architectures and thermodynamic cycles. It will support European engine manufacturers to pick up and keep pace with the US competitors, being alread...

Microscale poroelastic metamodel for efficient mesoscale bone remodelling simulations

Bone functional tissue adaptation is a multiaspect physiological process driven by interrelated mechanical and biological stimuli which requires the combined activity of osteoclasts and osteoblasts. In previous work, the authors developed a phenomenological mesoscale structural modelling approach capable of predicting internal structure of the femur based on daily activity loading, which relied...

Bone Structure and Bone Remodelling

Localized tissue mineralization regulated by bone remodelling: A computational approach

Bone is a living tissue whose main mechanical function is to provide stiffness, strength and protection to the body. Both stiffness and strength depend on the mineralization of the organic matrix, which is constantly being remodelled by the coordinated action of the bone multicellular units (BMUs). Due to the dynamics of both remodelling and mineralization, each sample of bone is composed of st...

Computational simulation of bone remodelling post reverse total shoulder arthroplasty

Bone is a living material. It adapts, in an optimal sense, to loading by changing its density and trabeculae architecture a process termed remodelling. Implanted orthopaedic devices can significantly alter the loading on the surrounding bone, which can have a detrimental impact on bone ingrowth that is critical to ensure secure implant fixation. In this contribution, a computational model that ...